Enantioselective Synthesis of 4-Isoxazolines by 1,3-Dipolar Cycloadditions of Nitrones to Alkynals Catalyzed by Fluorodiphenylmethylpyrrolidines
✍ Scribed by José Alemán; Alberto Fraile; Leyre Marzo; José Luis García Ruano; Cristina Izquierdo; Sergio Díaz-Tendero
- Book ID
- 111992682
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 892 KB
- Volume
- 354
- Category
- Article
- ISSN
- 1615-4150
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📜 SIMILAR VOLUMES
The cycloaddition reactions of in situ generated silyl nitronates 3 to chiral enone la or enoate l b proceed with high stereoselectivity to give enantiomericaUy pure N-silyloxyisoxazolidines 4, which can easily be transformed into A2-isuxazolines 5. Based on an X-ray analysis the major diastereomer
## Abstract magnified image The 1,3‐dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and isatin to 2,5‐bis(arylmethylidene)‐cyclopentanones afforded novel dispiro oxindole/pyrrolidines in moderate yields. Further cycloaddition of these dispiro oxindol