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Synthesis of trispiro[oxindole-pyrrolidine]-cyclopentanone-isoxazolines by 1,3-dipolar cycloaddition

✍ Scribed by Xiaofang Li; Aiting Zheng; Bin Liu; Xianyong Yu; Pinggui Yi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
117 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image The 1,3‐dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and isatin to 2,5‐bis(arylmethylidene)‐cyclopentanones afforded novel dispiro oxindole/pyrrolidines in moderate yields. Further cycloaddition of these dispiro oxindole/pyrrolidines with nitrile oxide afforded trispiro[oxindole‐pyrrolidine]‐cyclopentanone‐isoxazolines in moderate yields with high regio‐ and stereoselectivity. J. Heterocyclic Chem., (2010).

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✍ Xiaofang Li; Zhikui Li; Aiting Zheng; Guobin Li; Xianyong Yu; Pinggui Yi 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 119 KB

## Abstract The 1,3‐dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and isatin to 7‐arylmethylidene‐3‐aryl‐3,4‐dihydro‐2__H__‐thiazolo[3,2‐__a__][1,3,5]triazin‐6(7H)‐ones afforded novel dispiro[oxindole‐pyrrolidine]‐thiazolo[3,2‐__a__][1,3,5]triazine