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Enantioselective synthesis of 2-amino-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitriles using squaramide as the catalyst

โœ Scribed by Yu Gao; Da-Ming Du


Book ID
119375892
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
666 KB
Volume
23
Category
Article
ISSN
0957-4166

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Organocatalyzed synthesis of 2-amino-8-o
โœ Derong Ding; Cong-Gui Zhao ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 279 KB

2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition - cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles. An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% e