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Three-component synthesis of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chromene derivatives

โœ Scribed by Bian, Linglin; Xu, Jiechao; Xie, Liqing; Chen, Jie; Deng, Hongmei; Shao, Min; Ding, Tianling; Zhang, Hui; Cao, Weiguo


Book ID
120344173
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
235 KB
Volume
69
Category
Article
ISSN
0040-4020

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2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition - cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles. An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% e