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Enantioselective synthesis and CD assignment of absolute configuration of (−)-1,3-diphenylpropane-1,3-diol

✍ Scribed by Dario Pini; Alessandro Mandoli; Anna Iuliano; Piero Salvadori

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
177 KB
Volume
6
Category
Article
ISSN
0957-4166

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✦ Synopsis

Highly stereoselective hydrogenation of dibenzoylmethane in the presence of [RuCI2 {(R)-biphemp}] [biphemp = 2,2'-bis(diphenylphosphino)-6,6'-dimethyl-l,l'-biphenyl], in ethanol-dichloromethane, gives enantiomerically pure (-)-1,3-diphenylpropane-1,3-diol (2) (70% yield); analysis of the CD spectra of the corresponding acetonide allows the absolute configuration of the diol to be established as (S,S). The direct HPLC separation of the

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