✦ LIBER ✦

Synthesis and assignment of absolute configuration to the trans 3,4-dihydrodiols and 3,4-diol-1,2-epoxides of benzo[c]phenanthrene

✍ Scribed by H. Yagi; D.R. Thakker; Y. Ittah; M. Croisy-Delcey; D.M. Jerina

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 278 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)81653-6

No coin nor oath required. For personal study only.

✦ Synopsis

The (+)-and (-)-trans-3,4-dihydroxy-3,4-dihydrobenzo[c]phenanthrenes have been resolved and assigned absolute configuration by independent nmr and CD methods. Each was converted to its pair of diastereomeric bay-region 3,4-diol-1,2-epoxides in which the benzylic 4-hydroxyl group is either cis or trans to the epoxide oxygen. Benzo[c]phenanthrene is a widespread environmental pollutant la with weak tumorigenic activity on mouse skin. lb In accord with predictions of the bay-region theory, 2 its diastereomerit 3,4-diol-1,2-epoxides derived from the trans 3,4-dihydrodiol have been shown to possess

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Benzo[

ChemInform Abstract: Synthesis of Benzo[s]picene and Its Putative Carcinogenic trans-3,4-Dihydrodiol and Fjord Region anti-Diol Epoxide Metabolites.

✍ R. G. HARVEY; J.-T. ZHANG; E. LUNA; J. PATAKI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

Resolution and assignement of absolute c

Resolution and assignement of absolute configuration to the (+)- and (−)-cis and trans 3,4-diol metabolites of the anti-juvenile hormone precocene I

✍ Rita A. Halpin; Shaaban F. El-Naggar; Kenneth M. McCombe; Kamlesh P. Vyas; Derek 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 266 KB

Enantioselective Synthesis and Absolute

Enantioselective Synthesis and Absolute Configuration of the Natural threo-3-Chloro-1-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol.

✍ Qian Wang; Kan Kan He; Yun Zhong Li; Da Wei Li; Ying Li; Zi Jie Hou 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 18 KB 👁 1 views

Expression of a 32 kDa protein in rat ma

Expression of a 32 kDa protein in rat mammary tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide

✍ Ze'ev Ronai; Alla Polotskaya; Scott Gradia; Shantu Amin; Stephen S. Hecht 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 504 KB

Racemic anti-benzo[c]phenanthrene-3,4-diol-I ,2-epoxide (BcPDE) is a powerful rat mammary carcinogen and a metabolite of benzo[c]phenanthrene, a polynuclear aromatic hydrocarbon found in the environment. In elucidating potential molecular mechanisms that may play a role in the development of BcPDE-i

ChemInform Abstract: An Improved and Reg

ChemInform Abstract: An Improved and Regiospecific Synthesis of trans-3,4-Dihydrodiol Metabolite of Benzo[b]naphtho[2,1-d]thiophene.

✍ Subodh Kumar; Tae-Young Kim 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

ChemInform Abstract: A New and Concise S

ChemInform Abstract: A New and Concise Synthesis of 3-Hydroxybenzo[c]phenanthrene and 12-Hydroxybenzo[g]chrysene, Useful Intermediates for the Synthesis of Fjord-Region Diol Epoxides of Benzo[c]phenanthrene and Benzo[g]chrysene.

✍ S. KUMAR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 2 views