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NMR determination of the absolute configuration of chiral 1,2- and 1,3-diols

✍ Scribed by Hiroki Fukui; Yukiharu Fukushi; Satoshi Tahara

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
218 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Each of the chiral 1,2-and 1,3-diols examined was derivatized exclusively to a single diastereomeric acetal by the use of a new axially chiral reagent, 2%-methoxy-1,1%-binaphthalene-8-carbaldehyde (MBC). The absolute configuration of the original 1,2-and 1,3-diols was determined by the NOE correlation between the proton signals of the reagent moiety and those of the diol moiety in the acetals.

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