Enantioselective solid-phase synthesis of α-amino acid derivatives
✍ Scribed by Martin J. O'Donnell; Francisca Delgado; Richard S. Pottorf
- Book ID
- 108379323
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 964 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-ct-amino acids are obtained after cleavag
The first synthesis of N-aceOd-wamina acids by radical addition on solid support to commercialy available 2-acetamidoacrylic acid ~tng the merctey method is described The reaction proceeds in acceptable chemical efficiency (49-60~) depending on the nature of the mercury halide agent. Cleavage by mil