Enantioselective routes to 2,5-disubstituted- and 4-substituted-2-cyclohexenones
โ Scribed by Morio Asaoka; Toshiaki Aida; Syuzo Sonoda; Hisashi Takei
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 233 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
6-Alkyl-and 6-(1-alkenyl)-5-iodo-2-pyrones, which are available as major products by reaction of the corresponding (Z)-2-en-4-ynoic acids with iodine and NaHCO 3 in CH 3 CN, undergo insertion of activated zinc metal into their carbon iodine bond to provide the corresponding 5-(iodozinc)-2-pyrones. H
The synthesis of (S)-2-methyl tetrahydropyridine-N-oxide (4), a key intermediate for the enantioselective construction of trans-2,6-disubsdtuted piperidines via [3+2] nitrone cycloaddition reaction, is described. Nitrone 4 was elaborated to the fire ant venom alkaloid (+)-solenopsin-A (2) via interm