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An enantioselective route to trans-2,6-disubstituted piperidines

✍ Scribed by Samuel Chackalamannil; Yuguang Wang

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 390 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)00377-3

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✦ Synopsis

The synthesis of (S)-2-methyl tetrahydropyridine-N-oxide (4), a key intermediate for the enantioselective construction of trans-2,6-disubsdtuted piperidines via [3+2] nitrone cycloaddition reaction, is described. Nitrone 4 was elaborated to the fire ant venom alkaloid (+)-solenopsin-A (2) via intermediate 14.

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