Enantioselective preparation of allenecarboxylates by asymmetric horner-wadsworth-emmons reaction
✍ Scribed by Kiyoshi Tanaka; Kenji Otsubo; Kaoru Fuji
- Book ID
- 103405963
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 256 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The astonishingly simple chiral ligand 1 was used in the first asymmetric variant of the Horner-Wadsworth-Emmons reaction. The products of olefination of 4-substituted cyclohexanones with lithium phosphanates arise via the resulting hydroxyphosphonates, which are present in high enantiomeric excess
The enantioselective Horner-Wadsworth-Emmons reaction of 2-fluoro-2-diethylphosphonoacetates with s-symmetric prochiral 2-substituted-1,3-dioxan-5-ones and 4-substituted-cyclohexanones was investigated by employing Sn(OSO 2 CF 3 ) 2 and N-ethylpiperidine in the presence of an external chiral ligand,