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Kinetic Resolution of the Acrolein Dimer by Asymmetric Horner-Wadsworth-Emmons Reactions

✍ Scribed by Tobias Rein; Dipl.-Chem. Nina Kann; Dr. Reinhard Kreuder; Benoit Gangloff; Dr. Oliver Reiser


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
380 KB
Volume
33
Category
Article
ISSN
0044-8249

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The astonishingly simple chiral ligand 1 was used in the first asymmetric variant of the Horner-Wadsworth-Emmons reaction. The products of olefination of 4-substituted cyclohexanones with lithium phosphanates arise via the resulting hydroxyphosphonates, which are present in high enantiomeric excess