Enantioselective Preparation of 2,4-Disubstituted Azetidines

✍ Scribed by Angela Marinetti; Philippe Hubert; Jean-Pierre Genêt

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 265 KB
• Volume: 2000
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(200005)2000:9<1815::aid-ejoc1815>3.0.co;2-8

✦ Synopsis

Chiral C 2 -symmetric N-benzylazetidines have been conveniently prepared from optically pure anti-1,3-diols without loss of enantiomeric purity. N-Debenzylation led to the corresponding N-unsubstituted azetidines, which were then subjected to palladium-catalysed coupling reactions with aryl [a]