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Enantioselective Preparation of (2R)- and (2S)-Azetidine-2-carboxylic Acids

✍ Scribed by Pablo Wessig; Jutta Schwarz

Publisher
John Wiley and Sons
Year
1998
Tongue
German
Weight
181 KB
Volume
81
Category
Article
ISSN
0018-019X

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Chiral C 2 -symmetric N-benzylazetidines have been conveniently prepared from optically pure anti-1,3-diols without loss of enantiomeric purity. N-Debenzylation led to the corresponding N-unsubstituted azetidines, which were then subjected to palladium-catalysed coupling reactions with aryl [a]