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Enantioselective Michael Addition to α,β-Unsaturated Aldehydes: Combinatorial Catalyst Preparation and Screening, Reaction Optimization, and Mechanistic Studies

✍ Scribed by Ivana Fleischer; Andreas Pfaltz


Book ID
101838013
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
345 KB
Volume
16
Category
Article
ISSN
0947-6539

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✍ Jun Lu; Feng Liu; Teck-Peng Loh 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 1 views

## Abstract A pool of water‐compatible catalysts, namely dialkyl‐(__S__)‐prolinols, has been developed for the enantioselective direct vinylogous Michael addition reaction of vinylmalononitriles to α,β‐unsaturated aldehydes in aqueous medium. In many cases, the products can be obtained in almost op