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A Catalytic Enantioselective Michael Addition of a Simple Malonate to Prochiral α,β-Unsaturated Ketoses and Aldehydes

✍ Scribed by Prof. Dr. Masahiko Yamaguchi; Tai Shiraishi; Prof. Dr. Masahiro Hirama


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
373 KB
Volume
32
Category
Article
ISSN
0044-8249

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✍ Jun Lu; Feng Liu; Teck-Peng Loh 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

## Abstract A pool of water‐compatible catalysts, namely dialkyl‐(__S__)‐prolinols, has been developed for the enantioselective direct vinylogous Michael addition reaction of vinylmalononitriles to α,β‐unsaturated aldehydes in aqueous medium. In many cases, the products can be obtained in almost op