A General Organocatalytic Enantioselective Malonate Addition to α,β-Unsaturated Enones
✍ Scribed by Veit Wascholowski; Kristian Rahbek Knudsen; Claire E. T. Mitchell; Steven V. Ley
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 396 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0947-6539
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Even though the first reports of enantioselective organocatalysis by Wiechert et al. and Hajos and Parrish appeared almost three decades ago, [1] the field of asymmetric catalysis has been dominated by metal catalysis. It is only recently that asymmetric organocatalysis has received renewed attentio
## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.