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Enantioselective Michael Addition of Dicyanoolefins to α,β-Unsaturated Aldehydes in Aqueous Medium

✍ Scribed by Jun Lu; Feng Liu; Teck-Peng Loh

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 219 KB
Volume: 350
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200800145

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✦ Synopsis

Abstract

A pool of water‐compatible catalysts, namely dialkyl‐(S)‐prolinols, has been developed for the enantioselective direct vinylogous Michael addition reaction of vinylmalononitriles to α,β‐unsaturated aldehydes in aqueous medium. In many cases, the products can be obtained in almost optically pure form (>96% ee) after a single recrystallization.

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