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Enantioselective Enzymatic Desymmetrization of Prochiral Allenic Diols

✍ Scribed by Dipl.-Chem. Chicco Manzuna Sapu; Prof. Jan-E. Bäckvall; Dr. Jan Deska


Book ID
101573904
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
303 KB
Volume
50
Category
Article
ISSN
0044-8249

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Lipase-catalyzed enantioselective desymm
✍ Shuji Akai; Toshiaki Tsujino; Tadaatsu Naka; Kouichi Tanimoto; Yasuyuki Kita 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 62 KB

Oxindoles 3b-d (91-98% ee) having a chiral quaternary carbon center at the C-3 position were prepared from readily available oxindoles 5a-c in 50-64% overall yields, in which an enantioselective desymmetrization of prochiral 1,3-diols 2b-d using a Candida rugosa lipase (Meito OF) and 1-ethoxyvinyl 2