Enantioselective enzymatic desymmetrization of the prochiral pyrimidine acyclonucleoside
✍ Scribed by Renata Kołodziejska; Marcin Górecki; Jadwiga Frelek; Marcin Dramiński
- Book ID
- 116909644
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 651 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
Oxindoles 3b-d (91-98% ee) having a chiral quaternary carbon center at the C-3 position were prepared from readily available oxindoles 5a-c in 50-64% overall yields, in which an enantioselective desymmetrization of prochiral 1,3-diols 2b-d using a Candida rugosa lipase (Meito OF) and 1-ethoxyvinyl 2
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