Enantiomeric separation of some piperidine-2,6-dione drugs using chiralcel OJ-R column

✍ Scribed by Hassan Y. Aboul-Enein; Soliman A. Bakr

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 153 KB
• Volume: 9
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/(sici)1520-636x(1997)9:1<10::aid-chir2>3.0.co;2-k

✦ Synopsis

A newly developed reversed phase cellulose tris(4-methyl benzoate) known as Chiralcel OJ-R was used to investigate the chiral recognition and enantiomeric separation of eight racemic piperidine-2,6-dione compounds-namely, aminoglutethimide and its major metabolite acetylaminoglutethimide, glutethimide, cyclohexylaminoglutethimide, pyridoglutethimide, thalidomide, phenglutarimide, and 3-phenylacetylamino-2,6-piperidinedione (antineoplaston A-10). Chiral separation of these compounds was achieved under varying ratios of the mobile phase, except for phenglutarimide and 3-phenylacetylamino-2,6-piperidinedione, for which separation was unsuccessful. Possible chiral recognition mechanisms are also presented. Chirality 9: 10-12, 1997.