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Investigation of the enantioselectivity and enantiomeric elution order of some piperidine-2,6-dione drugs on chiralcel OD column

โœ Scribed by Dr. Hassan Y. Aboul-Enein; Vince Serignese


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
268 KB
Volume
6
Category
Article
ISSN
0899-0042

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๐Ÿ“œ SIMILAR VOLUMES


Enantiomeric separation of some piperidi
โœ Hassan Y. Aboul-Enein; Soliman A. Bakr ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 153 KB

A newly developed reversed phase cellulose tris(4-methyl benzoate) known as Chiralcel OJ-R was used to investigate the chiral recognition and enantiomeric separation of eight racemic piperidine-2,6-dione compounds-namely, aminoglutethimide and its major metabolite acetylaminoglutethimide, glutethimi

Influence of the nature and substitution
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A number of 2,3-epoxy alcohol derivatives (1-16), obtained either as racemates or through the Sharpless asymmetric epoxidation reaction, were studied on a Chiralcel OD column. Nearly all compounds exhibit good enantioselective resolution on this chiral support. The order of elution of enantiomers is