A newly developed reversed phase cellulose tris(4-methyl benzoate) known as Chiralcel OJ-R was used to investigate the chiral recognition and enantiomeric separation of eight racemic piperidine-2,6-dione compounds-namely, aminoglutethimide and its major metabolite acetylaminoglutethimide, glutethimi
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Investigation of the enantioselectivity and enantiomeric elution order of some piperidine-2,6-dione drugs on chiralcel OD column
โ Scribed by Dr. Hassan Y. Aboul-Enein; Vince Serignese
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 268 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0899-0042
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A number of 2,3-epoxy alcohol derivatives (1-16), obtained either as racemates or through the Sharpless asymmetric epoxidation reaction, were studied on a Chiralcel OD column. Nearly all compounds exhibit good enantioselective resolution on this chiral support. The order of elution of enantiomers is