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Enantiomeric separation of chiral peptide nucleic acid monomers by capillary electrophoresis with charged cyclodextrins

✍ Scribed by Gianni Galaverna; Stefano Sforza; Tullia Tedeschi; Roberto Corradini; Arnaldo Dossena; Rosangela Marchelli


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
87 KB
Volume
24
Category
Article
ISSN
0173-0835

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## Chiral separations by cyclodextrin-modified capillary electrophoresis -Determination of the enantiomeric excess The chiral nature of living systems has strong implications for biologically active compounds interacting with them. Consequently, the stereoisomers of drugs can differ in both pharma

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## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the ani