Enantiomeric separation of chiral peptide nucleic acid monomers by capillary electrophoresis with charged cyclodextrins
β Scribed by Gianni Galaverna; Stefano Sforza; Tullia Tedeschi; Roberto Corradini; Arnaldo Dossena; Rosangela Marchelli
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 87 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0173-0835
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## Chiral separations by cyclodextrin-modified capillary electrophoresis -Determination of the enantiomeric excess The chiral nature of living systems has strong implications for biologically active compounds interacting with them. Consequently, the stereoisomers of drugs can differ in both pharma
## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged Ξ²βcyclodextrin derivatives. The interaction of the analytes with the ani