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Enantiomeric separation of carboxylic acids having chiral centers remote from the carboxyl group by labelling with a chiral fluorescent derivatization reagent

✍ Scribed by Kazuaki Akasaka; Hiroshi Meguro; Hiroshi Ohrui

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
208 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Enantiomeric separations of 2-, 3-, 4-, 5-and 6-methyl fatty acids and 3-, 4and 5-hydroxy fatty acids derivatized with (S)-(+)-2-(anthracene-2,3-dicarboximido)-lpropyl trifluoromethanesulfonate are described. Although there are 4-8 bond distances between the chiral centers of these diastereomeric derivatives, they are separated on HPLC and detected at fmol levels, c0 1997 Elsevier Science Ltd.

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## Abstract The use of P(III) and P(V) organophosphorus derivatizing agents prepared from __C__~2~ symmetrical (1__R__,2__R__)‐ and (1__S__,2__S__)‐__trans__‐__N__,__N__′‐bis‐[(__S__)‐α‐phenylethyl]‐cyclohexane‐1,2‐diamines **1** and **2**, as well as (1__R__,2__R__)‐ and (1__S__,2__S__)‐__trans__‐