Enantiomeric Separation of some 2-Arylpropionic Acids with a Chiral Fluorescence Labelling Reagent by Narrow-Bore Liquid Chromatography
✍ Scribed by D. Pecanac; W. R. G. Baeyens; K. Imai; A. Van Overbeke; G. Van Der Weken; C. De Waele
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 83 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0269-3879
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📜 SIMILAR VOLUMES
Figure 1. Reaction of D/L-amino acids with R(À)-DBD-PyNCS.
The enantiomneric separation and the detection of 2-arylpropionic acids after derivatization with the fluorescent reagents with a benzofurazan structure, (S)-( + )-4-(N,N-dimethylaminosulphonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole ((S)-DBD-Apy), (R)-(-)-4-nitro-7-(3-aminopyrrolidin-1-yl)
## Abstract The usefulness of __R__(−)‐4‐(3‐isothiocyanatopyrrolidin‐1‐yl)‐7‐(__N,N__‐dimethylaminosulfonyl)‐2,1,3‐benzoxadiazole [__R__(−)‐DBD‐PyNCS], a fluorescent chiral tagging reagent, for the determination of racemic amines and amino acids, was studied. The reagent reacted with β‐blockers sel