Determination of the enantiomeric excess of chiral carboxylic acids by 31P NMR with phosphorylated derivatizing agents from C2-symmetrical diamines containing the (S)-α-phenylethyl group

✍ Scribed by Virginia M. Mastranzo; Leticia Quintero; Cecilia Anaya de Parrodi

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 192 KB
• Volume: 19
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.20406

✦ Synopsis

Abstract

The use of P(III) and P(V) organophosphorus derivatizing agents prepared from C~2~ symmetrical (1__R__,2__R__)‐ and (1__S__,2__S__)‐trans‐N,N′‐bis‐[(S)‐α‐phenylethyl]‐cyclohexane‐1,2‐diamines 1 and 2, as well as (1__R__,2__R__)‐ and (1__S__,2__S__)‐trans‐N,N′‐bis‐[(S)‐α‐phenylethyl]‐4‐cyclohexene‐1,2‐diamines 3 and 4 for the determination of enantiomeric composition of chiral carboxylic acids by ^31^P NMR, is described. Chirality, 2007. © 2007 Wiley‐Liss, Inc.