𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantiomeric Separation of (±)-Amino Acid Esters on (−)-Phenylurea Chiral Stationary Phase

✍ Scribed by Kwang-Pill Lee; Hyun-Bong Lee; Young Cheol Lee; Seong-Ho Choi; Jae Jeong Ryoo; Jung Hag Park

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
40 KB
Volume
63
Category
Article
ISSN
0026-265X

No coin nor oath required. For personal study only.

✦ Synopsis

The 3,5-dinitrobenzoyl (Ϯ)-amino acid esters were successfully resolved on (Ϫ)-phenylurea chiral stationary phases (CSPs) in a normal phase mode by high-performance liquid chromatography (HPLC). The alcohols used for esterification were methanol, ethanol, and n-propanol. The effects of esterification were studied via retention and optical resolution. The solvent and its concentration effect on enantioselectivity have been investigated based on the binary or ternary solvent system. The alcohol used in the binary or ternary solvent system was critical to the enantiomeric resolution of 3,5-dinitrobenzoyl amino acid esters while the nonalcoholic solvent was not suitable. The optical condition of the enantiomeric resolution is discussed in terms of the solvent composition and structure of the amino acid esters. The main chiral recognition mechanism based on theinteraction of the nitrobenzoyl group of the amino acid derivatives with the -basic phenyl group of CSPs is described.

📜 SIMILAR VOLUMES

Enantiomeric discrimination of pyrethroi
Enantiomeric discrimination of pyrethroic acid esters on polysaccharide derived chiral stationary phases
✍ Byoung-Hyoun Kim; Sang Uck Lee; Kun Tai Kim; Joo-Young Lee; Nak Hee Choi; Young- 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract Enantiomeric separation of pyrethroic acid methyl and ethyl esters was examined on cellulose‐based chiral stationary phases (CSPs): chiralcel OD (cellulose tris(3,5‐dimethylphenyl carbamate)) and chiralcel OF (cellulose tris(4‐chlorophenyl carbamate)). The good resolution of pyrethroic

Enantiomeric LC separation of calcium an
Enantiomeric LC separation of calcium antagonists on protein-based chiral stationary phases
✍ Dr. Ersilia De Lorenzi; Anthony F. Fell; Alan L. Holmes; Gabriele Caccialanza; G 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB 👁 1 views

Three chiral calcium antagonist drugs, bepridil and two dihydropyridine derivatives (nicardipine and REC 15123751, have been successfully separated within short retention times using either the a,-acid glycoprotein chiral stationary phase (Chiral AGP) or the ovomucoid column (Ultron ES-OW). Aqueous

Enantiomeric separation of amino alcohol
Enantiomeric separation of amino alcohols by gas chromatography on a chiral stationary phase; influence of the perfluoroacylating reagent on the separation
✍ Küsters, Ernst ;Portmann, Andrea 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB 👁 1 views

## Abstract Racemic amino alcohols have been separated as perfluoroacylated derivatives by gas chromatography using either improved Chirasil‐Val or heptakis(2,6‐di‐__O__‐methyl‐3‐__O__‐pentyl)‐β‐cyclodextrin as stationary phase. Using Chirasil‐Val all the amino alcohols investigated were separated