Enantiomeric separation of 2-chloropropionic acid by enzymatic esterification in organic solvents
✍ Scribed by J. Bodnár; L. Gubicza; L.-P. Szabó
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 489 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0304-5102
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## Abstract **Background:** This work reports the optimization of geranyl propionate production by esterification of geraniol and propionic acid in a solvent‐free system using a commercial lipase as catalyst. For this purpose, a sequential strategy was performed applying two experimental designs.
The improved enantioselectivities were observed for lipase MY-catalyzed esterifications of 2-phenoxypropionic acids in organic solvent at high reaction temperature. In this paper, we proposed an assumed model for explaining its high temperature-induced high enantioselectivity.
Substituent effects on the enantioselectivity for the lipase-catalyzed esterifications in organic solvents were studied by use of 2-(4-substituted phenoxy)propionic acids as the substrates with various substituents of H, F, Cl, CF 3 , CH 3 , CH 3 CH 2 , and CH 3 O. The distinction in the behavior of