Enantiomeric discrimination in the NMR spectra of underivatized amino acids and α-methyl amino acids using (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid
✍ Scribed by Thomas J Wenzel; Jolene E Thurston
- Book ID
- 108379749
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 117 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Enantiomeric discrimination is observed in the ^1^H and ^13^C NMR spectra of secondary and tertiary amines in the presence of (−)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid (**1**). Nonequivalence of the resonances of prochiral nuclei in primary and secondary amines is also observed wh
## Abstract Chiral discrimination studies using (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid (18‐C‐6‐TA) as a chiral selector were performed by high‐performance liquid chromatography (HPLC) and NMR spectroscopy. The enantiomers of alanine (Ala) or alanine methyl ester (Ala‐ME) were well separate