Enantiomer separation of disopyramide with capillary electrophoresis using various cyclodextrins
✍ Scribed by Dr. Zoltán Juvancz; Karin E. Markides; László Jicsinszky
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 483 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0173-0835
No coin nor oath required. For personal study only.
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## Abstract Chiral separation of tocainide, an antiarrythmic agent, was solved using the capillary electrophoresis method. Fifteen types of cyclodextrins were tried as chiral selective buffer additives, and baseline separation was achieved with five of them. The variables that were studied comprise
A negatively charged cyclodextrin, sulfated -cyclodextrin -CD-Ž y . x SO , was used as a chiral selector for capillary electrophoresis separations of 4 4 basic pharmaceutical enantiomers. The charges of the basic enantiomers were controlled by adjusting the buffer pH. At pH 2.5, basic compounds a