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Enantiomer separation of disopyramide with capillary electrophoresis using various cyclodextrins

✍ Scribed by Dr. Zoltán Juvancz; Karin E. Markides; László Jicsinszky


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
483 KB
Volume
18
Category
Article
ISSN
0173-0835

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## Abstract Chiral separation of tocainide, an antiarrythmic agent, was solved using the capillary electrophoresis method. Fifteen types of cyclodextrins were tried as chiral selective buffer additives, and baseline separation was achieved with five of them. The variables that were studied comprise

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A negatively charged cyclodextrin, sulfated ␤-cyclodextrin ␤-CD-Ž y . x SO , was used as a chiral selector for capillary electrophoresis separations of 4 4 basic pharmaceutical enantiomers. The charges of the basic enantiomers were controlled by adjusting the buffer pH. At pH 2.5, basic compounds a