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Enantiomer and diastereomer resolution of dipeptides by gas chromatography on chirasil-val

✍ Scribed by Koppenhoefer, B. ;Allmendinger, H. ;Bayer, E.

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 338 KB
Volume: 10
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240100518

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✦ Synopsis

Several dipeptides have been separated into stereoisomers (enantiomers, diastereoisomers, sequential isomers) by GC on the chiral stationary phase Chirasil-Val. Sufficiently volatile N-TFA-dipeptide methyl esters have been formed by derivatization at ambient temperature, thus avoiding racemization (or epimerization, respectively), and peptide cleavage. This novel approach has proven particularly useful for the determination of stereoisomeric composition of dipeptides in biological fluids. ') Fused silica capillary columns coated with either L-or D-Chirasil-Val are commercially available from Chrompack, Middelburg, NL.

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