Enantiodivergent Synthesis of the Key Intermediate for Aphanorphine by Chemoenzymatic Process
β Scribed by Keith O. Hallinan; Toshio Honda
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 432 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
Efficient, formal syntheses of aphanorphine and eptazocine are reported that involve epoxide cyclizations. The necessary chiral epoxides were prepared following treatment of diols prepared by Sharpless asymmetric osmylations of an alkene. The cyclizations formed a ring compound with the same enantio
A key intermediate ( ) in its optically active form. P for the total synthesis of streptovaricin A (A) is synthesized urther elaboration of 2 is also described. Streptovaricin A (J,), produced by Streptomyces spectabilis, is an ansamycin antibiotic with notable antitumor activity. 1 The streptovar