Classical segregation analysis was performed on 651 male probands in 597 families with Duchenne muscular dystrophy (DMD) collected from 20 of 25 National Institutions for Muscle Diseases in Japan. The proportion of sporadic cases is compatible with 1/3 expected for an X-linked lethal trait with an e
EMG computerized analysis of localized fatigue in duchenne muscular dystrophy
β Scribed by Dr. Massimo Frascarelli; Letizia Rocchi; Isidoro Feola
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 342 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
β¦ Synopsis
EMG power spectra obtained during a sustained isometric contraction were analyzed in a group of 10 children affected by Duchenne muscular dystrophy (DMD) and compared with those obtained in a control group of 5 normal children. In myopathic subjects the isometric contraction caused an increase of the total power, a progressive increase of power of the lower frequencies, a decrease of that of the higher frequencies, and a shift downward of the median frequency. In normal children an increase of the total power without a significant median frequency shift was noted. The modifications observed in DMD children were explained by a decrement of the firing rate of the more damaged fast twitch motor units. This decrease was probably induced by a relative predominance of activity of the slow twitch motor units, which are less damaged by the pathological process.
π SIMILAR VOLUMES
We studied 48 patients with dystrophinopathies (29 Duchenne muscular dystrophy (DMD), 13 Becker muscular dystrophy (BMD), four possible carriers, one female with DMD, and one intermediate form, using polymerase chain reaction (PCR) analysis of muscle tissue for 20 exons and compared them with immuno
## Introduction: Duchenne/becker muscular dystrophies (dmd/bmd) are x-linked recessive diseases caused by mutations in the dystrophin gene. ## Methods: We used multiplex polymerase chain reaction (pcr) and short tandem repeat (str) segregation analysis for dmd/bmd-carrier detection and prenatal d