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Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L

✍ Scribed by Roberta Di Pietro; Giorgio Zauli

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
232 KB
Volume
201
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super‐family and 21 different receptors have been identified. All ligands of the TNF super‐family have been found to activate transcription factor NF‐κB and c‐Jun kinase. Members of this family have diverse biological effects, including induction of apoptosis, promotion of cell survival, and regulation of the immune system and hematopoiesis. The current review focuses on the biological effects of TNF‐related apoptosis‐inducing ligand (TRAIL), a TNF super‐family member which, a few years ago, generated considerable enthusiasm for its anticancer activity, not accompanied by general toxicity in most normal tissues and organs. © 2004 Wiley‐Liss, Inc.

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