## Abstract Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super‐family and 21 different receptors have been identified. All ligands of the TNF super‐family have been found to activate transcription factor NF‐κB and c‐Jun kinase. Mem
Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor–related apoptosis-inducing ligand (TRAIL)
✍ Scribed by Frans Van Valen; Simone Fulda; Borna Truckenbrod; Vera Eckervogt; Jürgen Sonnemann; Axel Hillmann; Robert Rödl; Christiane Hoffmann; Winfried Winkelmann; Lutz Schäfer; Barbara Dockhorn-Dworniczak; Torsten Wessel; Joachim Boos; Klaus-Michael Debatin; Herbert Jürgens
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 176 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) has been shown to induce apoptosis in numerous transformed cell lines but not in most normal cells. Although this selectivity offers a potential therapeutic application in cancer, not all cancers are sensitive to TRAIL‐medi
## Abstract This paper describes a method about the crystal shape control improving the anti‐tumor activity of tumor necrosis factor‐related apoptosis‐inducing ligand (Apo2L/TRAIL) in a batch cooling suspension crystallization by selecting pH values as a controllable variable. Three shaped TRAIL cr