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Emergence of the precore mutant late in chronic hepatitis B infection correlates with the severity of liver injury and mutations in the core region

✍ Scribed by Toshiyuki Maruyama; Hiroshi Mitsui; Hisato Maekawa; Haruki Yamada; Miki Hirayama; Shiro Iino; Kiyomi Yasuda; Kazuhiko Koike; Satoshi Kimura; David R Milich

Book ID: 119389966
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 233 KB
Volume: 95
Category: Article
ISSN: 0002-9270
DOI: 10.1016/s0002-9270(00)01994-8

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The involvement of precore stop codon 1896-A and base exchanges in the AT-rich region at positions 1762 and 1764 of the hepatitis B core promotor has been controversely discussed in adults with fulminant hepatitis B. Because no data are currently available on children, we analyzed the basic core pro

Mutations in the hepatitis B virus preco

Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation

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and who developed recurrent HBV infection were evaluated for the study. Patients infected Abbreviations: HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; nt, nucleowith hepatitis C or delta virus were excluded, leaving a study group tide; HBeAg, hepatitis B e antigen; PCR, polymerase chai