The precore mutation is associated with severity of liver damage in Brazilian patients with chronic hepatitis B
✍ Scribed by Rosamar E.F. Rezende; Benedito A.L. Fonseca; Leandra N.Z. Ramalho; Sérgio Zucoloto; João Renato R. Pinho; Dennis A. Bertolini; Ana L.C. Martinelli
- Book ID
- 116630689
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 103 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1386-6532
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Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e
## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in