Embolization of calcific thrombi after tissue plasminogen activator treatment
โ Scribed by Brett M. Kissela; Rashmi U. Kothari; Thomas A. Tomsick; Daniel Woo; Joseph Broderick
- Book ID
- 117827968
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 77 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1532-8511
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The in vitro functional properties of recombinant tissue plasminogen activator (rt-PA), its biodistribution in mice, and its pharmacokinetics and clot localization properties in dogs have been investigated after labeling rt-PA with 111In. The rt-PA was coupled with the bicyclic anhydride of DTPA usi
We report the use of centrally administered tissue-type plasminogen activator for three patients who presented with massive pulmonary embolism to the emergency department. In all patients, rapid improvement of pulmonary arterial pressures ensued by the end of the drug infusion, while the presenting