Treatment of massive pulmonary embolism with centrally administered tissue-type plasminogen activator
β Scribed by Subodh K Mohindra; George O Udeani
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 404 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1097-6760
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β¦ Synopsis
We report the use of centrally administered tissue-type plasminogen activator for three patients who presented with massive pulmonary embolism to the emergency department. In all patients, rapid improvement of pulmonary arterial pressures ensued by the end of the drug infusion, while the presenting symptoms of chest pain and shortness of breath subsided.
π SIMILAR VOLUMES
The efficacy and safety of recombinant tissue-type plasminogen activator (rt-PA) was evaluated in 46 patients with thrombembolic arterial occlusions in leg arteries, rt-PA was given over 1-4 h with a maximum dose of 18 mg. The effect of rt-PA treatment was determined as patency of the occluded arter