Characterization of human cytochrome P45
Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone
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Atsushi Kitamura; Yoshiko Mizuno; Kiyoshi Natsui; Masashi Yabuki; Setsuko Komuro
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Article
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2005
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John Wiley and Sons
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English
โ 350 KB
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In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic