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Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

✍ Scribed by Szybka, M; Zawlik, I; Kulczycka, D; Golanska, E; Jesien, E; Kupnicka, D; Stawski, R; Piaskowski, S; Bieniek, E; Zakrzewska, M


Book ID
109999429
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
97 KB
Volume
98
Category
Article
ISSN
0007-0920

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p53 protein is a transcription factor involved in multiple tumor-suppressor activities including cell cycle control and apoptosis. TP53 gene is frequently mutated in glioblastoma, suggesting the importance of inactivation of this gene product in gliomagenesis. Restoration of p53 function in glioblas