A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
β Scribed by Van Meir, Erwin G.; Polverini, Peter J.; Chazin, Victoria R.; Su Huang, H.-J.; de Tribolet, Nicolas; Cavenee, Webster K.
- Book ID
- 109918244
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 731 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1061-4036
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## Abstract The __p53__ gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. A __p53__βnull murine osteosarcoma cell line F6 was transfected with either a wildβtype or a mutant __p53__ gene. Stably transfected cell lines were obtained, and their d