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Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

✍ Scribed by Van Meir, Erwin G.; Polverini, Peter J.; Chazin, Victoria R.; Su Huang, H.-J.; de Tribolet, Nicolas; Cavenee, Webster K.


Book ID
109918244
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
731 KB
Volume
8
Category
Article
ISSN
1061-4036

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## Abstract The __p53__ gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. A __p53__‐null murine osteosarcoma cell line F6 was transfected with either a wild‐type or a mutant __p53__ gene. Stably transfected cell lines were obtained, and their d