Synthetic studies of pseudolaric acid B, 2, provided a relay synthesis of pseudolaric acid B (PLAB) via aldehyde 5. The aldehyde 5 can serve: to complete the total synthesis of PLAB; as a precursor for the synthesis of PLAB analogs; or as a substrate for the generation of radiolabeled PLAB for mecha
Elimination of transamination side product by the use of dCAc methylphosphonamidite in the synthesis of oligonucleoside methylphosphonates
β Scribed by M.P Reddy; Firdous Farooqui; Naeem B Hanna
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 196 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The transamination side product formed by the use of dC bz or dC *~ methylphosphonamidite upon treatment with ethylenediamine has been eliminated by the use of dC Ac methylphosphonamidite. The synthesis and characterization of DMT dC Ac methylphosphonamidite is described.
π SIMILAR VOLUMES
The tetrasaccharide beta-D-Galp-(1----4)-beta-D-GlcpNAc-(1----6)-alpha-D- Manp-(1----6)-beta-D-Manp-OR (2) and the pentasaccharide beta-D-GlcpNAc-(1----3)-beta-D-Galp-(1----4)-beta-D- GlcpNAc-(1----6)-alpha-D-Manp-(1----6)-beta-D-Manp-OR (3), where R = (CH2)8COOMe, have been prepared by using combin