Elimination of contaminant kryptofix 2.2.2 in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose
β Scribed by Stephen M. Moerlein; James W. Brodack; Barry A. Siegel; Michael J. Welch
- Publisher
- Elsevier Science
- Year
- 1989
- Weight
- 167 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0883-2889
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The presence of 2-deoxy-2-['sF]fluoro-D-mannose (['sF]FDM) in 2-deoxy-2-['\*F]fluoro-o-glucose (['aF]FDG) prepared by the reaction of 3,4,6-tri-0-acetyi-D-glucal (TAG) with ['\*F]acetyl hypofluorite ([r\*F]CHsCOOF) or ['sF]Fr was quantified by radio HPLC analysis of reacetylated ['\*F]FDG. The solve
Using existing robotic hardware and software programs developed for the synthesis of several positron-emitting radiopharmaceuticals for PET imaging [Brodack et al. (1988) Appl. Radiat. Isot. 39, 689], the additional automated synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) has been incorpo