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Elevation of platelet-associated IgG in aplastic anemia

✍ Scribed by Ryuji Kawaguchi; Shoji Haruna; Kazumasa Hikiji; Yasuko Higashi; Yutaka Tsukada

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 501 KB
Volume: 6
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860060306

No coin nor oath required. For personal study only.

✦ Synopsis

We determined platelet-associated IgG (PAIgG) levels in patients with aplastic anemia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, and systemic lupus erythematosus (SLE), as well as in normal healthy adults as a control group. To determine PAlgG levels, we used a competitive micro enzyme-linked immunosorbent assay, which had excellent reproducibility, recovery, and dilution. We confirmed its reliability by comparing it to the immunoradiometric assay. Both the aplastic anemia group (n = 27, mean ~~ ? SD = 21 8.6 & 244.6 ng/l O7 platelets) and theITPgroup(n = 82,mean k SD = 212.5 & 327.8 ng/l O7 platelets) had higher PAlgG levels than the SLE group (n = 4, mean ? SD = 38.4 -t 22.4 ng/107 platelets), iron deficiency anemia group (n = 10, mean f SD = 16.1 * 3.6 ngil O7 platelets), and normal control group (n = 69, mean & SD = 16.1 -c 3.6 ngll O7 platelets. The higher plateletassociated IgG levels in aplastic anemia suggest that autoimmune mechanisms are involved. o 1992 Wiley-tiss. Inc.

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