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Treatment of platelet-alloimmunization with cyclosporin a in a patient with aplastic anemia

✍ Scribed by Masahiro Yamamoto; Hiroshi Ideguchi; Junji Nishimura; Hajime Nawata; Shoichi Inaba; Kazuo Tokunaga; Hiroyuki Kiyokawa; Yoshiaki Maeda

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
189 KB
Volume
33
Category
Article
ISSN
0361-8609

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✦ Synopsis

The development of alloantibodies to platelets is a major problem in the supportive management of thrombocytopenia in patients with severe aplastic anemia. We report here a case of aplastic anemia refractory to platelet transfusion. An immunosuppressant, cyclosporin A, which was used for the therapy of aplastic anemia, modulated alloimmunization to platelets in this patient, followed by repeated platelet transfusion. The treatment reduced platelet alloantibodies detected by anti-human immunoglobulin lymphocytotoxicity test, with change of the CD4/CD8 ratio in T lymphocytes in peripheral blood.

These results suggest the usefulness of cyclosporin A for the prevention of platelet alloimmunization.

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Treatment of platelet alloimmunization with intravenous immunoglobulin in a child with aplastic anemia
✍ Dr. Shu-Huey Chen; Der-Cherng Liang; Marie Lin πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 221 KB πŸ‘ 1 views

A %year-old girl with severe refractory aplastic anemia had become refractory to platelet transfusion due to platelet alloimmunization. As a result, a huge right parieto-temporooccipital cerebral hematoma and a subarachnoid hemorrhage subsequently occurred. Intravenous immunoglobulin (IVIG) (Green C