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Elevated expression of epidermal ornithine decarboxylase mRNA in scleroderma

✍ Scribed by Ohtsuka; Koibuchi; Matsuzaki; Yamakage; Yamazaki

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
187 KB
Volume
139
Category
Article
ISSN
0007-0963

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✦ Synopsis

Using in situ hybridization techniques, we examined the expression of ornithine decarboxylase (ODC) mRNA in the skin of five patients with systemic sclerosis (SSc) and five normal controls. Sections treated with an anti-sense probe showed concentrated grains exclusively in the epidermis of SSc patients, but not in that of normal controls. Because our subcloned anti-sense probe specifically hybridizes with ODC mRNA, these findings indicate that the expression of ODC mRNA is elevated in SSc epidermis. Possibly polyamines have an important part to play in the skin changes of SSc.

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