Elevated concentrations of 15-deoxy-Δ12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor γ-inducing drugs
✍ Scribed by Olav A. Gressner; Chunfang Gao; Katharina Rehbein; Birgit Lahme; Monika Siluschek; Thomas Berg; Tobias Müller; Axel M. Gressner
- Book ID
- 111238028
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 179 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0106-9543
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## Abstract 15‐deoxy‐Δ^12,14^ prostaglandin J~2~ (15dPGJ~2~), a peroxisome proliferator‐activated receptor gamma (PPARγ) ligand, induced synergistic stimulation of DNA synthesis in the presence of phorbol dibutyrate (PDB) in Swiss 3T3 cells. This effect was dose‐dependent and the maximum response w