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Electrostatic Interactions Regulate Desensitization of the Nicotinic Acetylcholine Receptor

✍ Scribed by Song, Xing-Zhi; Pedersen, Steen E.


Book ID
118513856
Publisher
Biophysical Society
Year
2000
Tongue
English
Weight
205 KB
Volume
78
Category
Article
ISSN
0006-3495

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The interaction of diisopropylfluorophosphate (DFP) with the nicotinic acetylcholine (ACh) receptor of Torpedo electric organ was studied, using [3H]-phencyclidine ([3H]-PCP) as a reporter probe. Phencyclidine binds with different kinetics to resting, activated, and desensitized receptor conformatio