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Electrospray mass spectrometry of angiotensin-converting enzyme inhibitors

✍ Scribed by M. Helena Florêncio; M. Tereza Fernandez; M. Lurdes Mira; Allan Millar; Keith R. Jennings

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
68 KB
Volume
12
Category
Article
ISSN
0951-4198

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✦ Synopsis

Electrospray ionisation (ESI) mass spectrometry combined with collision-induced decomposition of ions given by captopril, lisinopril and enalaprilat, angiotensin-converting enzyme (ACE) inhibitors, has been used to characterise these compounds. As expected, the ESI mass spectra are characterised by the presence of abundant [M H] ions with very little fragmentation at low cone voltages.

Fragment ions are produced by collision-induced decomposition of these ions at higher cone voltages, and in MS/MS experiments. Fragmentation pathways and structures of fragment ions observed have been proposed.

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